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Get PDF The Migraine Handbook: The Definitive Guide to the Causes, Symptoms and Treatments

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In the event of protocol amendments, the date of each amendment will be accompanied by a description of the change and the rationale. In addition, for Comparative Effectiveness reviews, the key questions were posted for public comment and finalized by the EPC after review of the comments. Key Informants represent a variety of stakeholder groups that are the end users of research, including patients and caregivers, practicing clinicians, relevant professional and consumer organizations, purchasers of health care, and others with experience in making health care decisions.

Within the EPC program, the Key Informants provide input into identifying the Key Questions for research that will inform healthcare decisions. The EPC will solicit input from Key Informants when developing questions for systematic review or when identifying high priority research gaps and needed new research.

Key Informants will not involved in analyzing the evidence or writing the report and have not reviewed the report, except as given the opportunity to do so through the peer or public review mechanism. Because of their role as end-users, individuals are invited to serve as Key Informants and those who present with potential conflicts may be retained. Technical Experts comprise a multi-disciplinary group of clinical, content, and methodological experts who provide input in defining populations, interventions, comparisons, or outcomes as well as identifying particular studies or databases to search.

They are selected to provide broad expertise and perspectives specific to the topic under development. Divergent and conflicted opinions are common and perceived as healthy scientific discourse that results in a thoughtful, relevant systematic review. Technical Experts provide information to the EPC to identify literature search strategies and recommend approaches to specific issues as requested by the EPC.

Technical Experts do not do analysis of any kind nor contribute to the writing of the report and have not reviewed the report, except as given the opportunity to do so through the public review mechanism. Because of their unique clinical or content expertise, individuals are invited to serve as Technical Experts and those who present with potential conflicts may be retained.

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The Migraine Handbook : The Definitive Guide to the Causes, Symptoms and Treatments

Peer reviewers are invited to provide written comments on the draft report based on their clinical, content, or methodological expertise. Peer review comments on the preliminary draft of the report are considered by the EPC in preparation of the final draft of the report. Peer reviewers do not participate in writing or editing of the final report or other products.

Background and Objectives for the Systematic Review

The synthesis of the scientific literature presented in the final report does not necessarily represent the views of individual reviewers. The dispositions of the peer review comments are documented and will, for CERs and Technical Briefs, be published three months after the publication of the Evidence report. Peer reviewers who disclose potential business or professional conflicts of interest may submit comments on draft reports through the public comment mechanism. Approximately 6—7 experts in the field of headache and migraine will be asked to peer review the draft report and provide comments.

IM or intra? IV or intra? Search Effective Health Care website Submit search. Background and Objectives for the Systematic Review Migraine is a neurovascular disorder characterized by dysfunction of the central and peripheral nervous systems and intracranial vasculature. Side effects The second objective of this CER is to assess important immediate and longer term side effects of the different interventions. Prevention of Recurrence Some patients with status migrainosus suffer a short-term recurrence that results in a return visit to a physician or ED.

Review Rationale The research used to support current guidelines for treatment of acute migraine is dated, not adequately synthesized, insufficient, and continues to add to clinical uncertainty, resulting in wide variation of practice. Following review of the comments and discussion with the Key Informants, AHRQ, and the Eisenberg Center, no changes were made to the original KQs; however, the following comments were incorporated into the background material or inclusion criteria, as appropriate: The importance of distinguishing between recurrent headache and recurrent visits to the ED.

The consideration of combinations of treatments. Addressing sedation as an adverse event.